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KMID : 0380019950100030257
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Korean Journal of Biotechnology and Bioengineering
1995 Volume.10 No. 3 p.257 ~ p.262
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Studies on the Fractional Precipitation of Dextran by Nonsolvent Addition Method
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Abstract
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Fractional precipitation of "native"dextran by the method of nonsolvent addition was studied. Precipitational phenomenon of fractioned dextran was characterized with the quantitative determination of the precipitational capacity of nonsolvents with different dielectric constants. Based upon this characterization, the fractional precipitation process for the dextran production was developed. From the precipitational characteristics, a first-order relationship between the molecular weight of fractioned dextran and the content of nonsolvents was formulated. The slopes of the first-order equation were correlated with the dielectric constants of the nonslovents. A modified fractionation process was constructed on the basis of refractionation method and employed to increase the efficiency of the controlled production of dextran.
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